Mycobacterium smegmatis Bacteria Expressing Mycobacterium tuberculosis-Specific Rv1954A Induce Macrophage Activation and Modulate the Immune Response

Mycobacterium tuberculosis (M. tb), the intracellular pathogen inflicting tuberculosis, has developed mechanisms that endow infectivity and permit it to modulate host immune response for its survival. Genomic and proteomic analyses of non-pathogenic and pathogenic mycobacteria confirmed presence of genes and proteins which can be particular to M. tb. In silico research predicted that M.tb Rv1954A is a hypothetical secretory protein that reveals intrinsically disordered areas and possess B cell/T cell epitopes.

Treatment of macrophages with Rv1954A led to TLR4-mediated activation with concomitant improve in secretion of pro-inflammatory cytokines, IL-12 and TNF-α. In vitro research confirmed that rRv1954A protein or Rv1954A knock-in M. smegmatis (Ms_Rv1954A) prompts macrophages by enhancing the expression of CD80 and CD86.

An upregulation in the expression of CD40 and MHC I/II was famous in the presence of Rv1954A, pointing to its function in enhancing the affiliation of APCs with T cells and in the modulation of antigen presentation, respectively. Ms_Rv1954A confirmed elevated infectivity, induction of ROS and RNS, and apoptosis in RAW264.7 macrophage cells. Rv1954A imparted safety in opposition to oxidative and nitrosative stress, thereby enhancing the survival of Ms_Rv1954A inside macrophages.

Mice immunized with Ms_Rv1954A confirmed that splenomegaly and primed splenocytes restimulated with Rv1954A elicited a Th1 response. Infection of Ms_Rv1954A in mice by intratracheal instillation results in enhanced infiltration of lymphocytes in the lungs with out formation of granuloma. While Rv1954A is immunogenic, it didn’t trigger hostile pathology. Purified Rv1954A or Rv1954A knock-in M.

smegmatis (Ms_Rv1954A) elicited an almost two-fold increased titer of IgG response in mice, and PTB sufferers possess the next IgG titer in opposition to Rv1954A, additionally pointing to its utility as a diagnostic marker for TB. The noticed modulation of innate and adaptive immunity renders Rv1954A an important protein in the pathophysiology of this pathogen.

Cancer-Associated Fibroblasts-Derived Exosomes Suppress Immune Cell Function in Breast Cancer by way of the miR-92/PD-L1 Pathway

Cancer-associated fibroblasts (CAFs) are a vital part in the tumor microenvironment and have been reported to contribute to tumor development by many mechanisms; nevertheless, the detailed mechanism underlying the immune-suppression impact of CAFs shouldn’t be clearly outlined.

In this examine, human breast cancer-derived CAFs had been cultured, and CAF-derived exosomes in a tradition medium had been remoted. Using a miRNA profiles assay, we establish a considerably increased degree of microRNA-92 remoted in CAFs exosomes. After remedy by CAF-derived exosomes, breast most cancers cells specific increased programmed cell demise receptor ligand 1 (PD-L1), accompanied with elevated miR-92 expression.

Increased PD-L1 expression, which was induced by CAF-derived exosomes, considerably promotes apoptosis and impaired proliferation of T cells. The underlying mechanism of this impact was studied, proliferation and migration of breast most cancers cells had been elevated after the transfection of miR-92, LATS2 was acknowledged as a goal gene of miR-92, and additional confirmed by a luciferase assay.

Immunoprecipitation confirmed that LATS2 can work together with YAP1, chromatin immunoprecipitation confirmed that after nuclear translocation YAP1 might bind to the enhancer area of PD-L1 to promotes transcription exercise. Furthermore, the animal examine confirmed that CAFs considerably promoted tumor development and impaired the operate of tumor-infiltrated immune cells in vivo. Our information revealed a novel mechanism that may induce immune suppression in the tumor microenvironment.

Crossing boundaries: Interplay between the immune system and oligodendrocyte lineage cells

Oligodendrocytes and their progenitors are glial cells in the central nervous system, which have been primarily implicated with the homeostatic roles of axonal myelin ensheathment however function targets of the peripheral immune system assault in the context of ailments like a number of sclerosis.

This view of oligodendroglia as passive bystanders with no immunological properties was first challenged in the 1980s when it was reported that the cytokine interferon γ might induce the gene expression of the main histocompatibility complexes (MHC) class I and II. While the physiological function of this induction was controversial for many years to observe, current research counsel that oligodendroglia survey their setting, reply to a bigger array of cues and can certainly exert immunomodulatory features, that are notably related in the context of neurodegeneration and demyelinating ailments.

The various performance of oligodendroglia not solely regulates immune cell responses, but additionally hinders remyelination, and would possibly thereby be key to understanding MS illness pathology and selling regeneration after immune-mediated demyelination.

[Two serial events of delayed hemolytic transfusion reactions due to different primary immune response-induced irregular antibodies]

A 74-year-old lady with a historical past of pregnancies, however with out earlier transfusions, obtained a purple blood cell transfusion for aplstic anemia. She misplaced consciousness on account of extreme anemia two weeks later and was transported by ambulance to our hospital. Delayed hemolytic transfusion response (DHTR) was recognized based mostly on the detection of anti-E antibody and optimistic E antigen of the beforehand transfused product.

A transfusion of E antigen-negative purple cell merchandise was carried out. However, DHTR on account of anti-c antibody developed 16 d after the transfusion of a c antigen-positive product. Based on the onset of ≥14 d after the transfusions and the detection of a causative IgM-type antibody, DHTR on account of a major immune response was recognized. Because the incidence of DHTR is low, physicians hardly ever expertise it in scientific follow.

Rabbit Autoimmune Regulator ELISA kit
E04A0527-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A sandwich ELISA for quantitative measurement of Rabbit Autoimmune Regulator in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Autoimmune Regulator ELISA kit
E03A0527-192T	BlueGene	192 tests	EUR 1270
Description: A sandwich ELISA for quantitative measurement of Mouse Autoimmune Regulator in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Autoimmune Regulator ELISA kit
E03A0527-48	BlueGene	1 plate of 48 wells	EUR 520
Description: A sandwich ELISA for quantitative measurement of Mouse Autoimmune Regulator in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Autoimmune Regulator ELISA kit
E03A0527-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A sandwich ELISA for quantitative measurement of Mouse Autoimmune Regulator in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Autoimmune Regulator ELISA kit
E07A0527-192T	BlueGene	192 tests	EUR 1270
Description: A sandwich ELISA for quantitative measurement of Porcine Autoimmune Regulator in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Autoimmune Regulator ELISA kit
E07A0527-48	BlueGene	1 plate of 48 wells	EUR 520
Description: A sandwich ELISA for quantitative measurement of Porcine Autoimmune Regulator in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Autoimmune Regulator ELISA kit
E07A0527-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A sandwich ELISA for quantitative measurement of Porcine Autoimmune Regulator in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Autoimmune Regulator ELISA kit
E09A0527-192T	BlueGene	192 tests	EUR 1270
Description: A sandwich ELISA for quantitative measurement of Monkey Autoimmune Regulator in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Autoimmune Regulator ELISA kit
E09A0527-48	BlueGene	1 plate of 48 wells	EUR 520
Description: A sandwich ELISA for quantitative measurement of Monkey Autoimmune Regulator in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Autoimmune Regulator ELISA kit
E09A0527-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A sandwich ELISA for quantitative measurement of Monkey Autoimmune Regulator in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Autoimmune Regulator ELISA kit
E06A0527-192T	BlueGene	192 tests	EUR 1270
Description: A sandwich ELISA for quantitative measurement of Goat Autoimmune Regulator in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Autoimmune Regulator ELISA kit
E06A0527-48	BlueGene	1 plate of 48 wells	EUR 520
Description: A sandwich ELISA for quantitative measurement of Goat Autoimmune Regulator in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Autoimmune Regulator ELISA kit
E06A0527-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A sandwich ELISA for quantitative measurement of Goat Autoimmune Regulator in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Autoimmune Regulator ELISA kit
E08A0527-192T	BlueGene	192 tests	EUR 1270
Description: A sandwich ELISA for quantitative measurement of Canine Autoimmune Regulator in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Autoimmune Regulator ELISA kit
E08A0527-48	BlueGene	1 plate of 48 wells	EUR 520
Description: A sandwich ELISA for quantitative measurement of Canine Autoimmune Regulator in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Autoimmune Regulator ELISA kit
E08A0527-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A sandwich ELISA for quantitative measurement of Canine Autoimmune Regulator in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Autoimmune regulator, AIRE ELISA KIT
ELI-12083h	Lifescience Market	96 Tests	EUR 824

Human Autoimmune Regulator (AIRE) ELISA Kit
SEC322Hu-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	EUR 4731.5
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Autoimmune Regulator (AIRE) in Tissue homogenates and other biological fluids.

Human Autoimmune Regulator (AIRE) ELISA Kit
SEC322Hu-1x48wellstestplate	Cloud-Clone	1x48-wells test plate	EUR 477.3
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Autoimmune Regulator (AIRE) in Tissue homogenates and other biological fluids.

Human Autoimmune Regulator (AIRE) ELISA Kit
SEC322Hu-1x96wellstestplate	Cloud-Clone	1x96-wells test plate	EUR 639
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Autoimmune Regulator (AIRE) in Tissue homogenates and other biological fluids.

Human Autoimmune Regulator (AIRE) ELISA Kit
SEC322Hu-5x96wellstestplate	Cloud-Clone	5x96-wells test plate	EUR 2575.5
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Autoimmune Regulator (AIRE) in Tissue homogenates and other biological fluids.

Human Autoimmune Regulator (AIRE) ELISA Kit
4-SEC322Hu	Cloud-Clone	EUR 4782.00 EUR 2526.00 EUR 640.00	10 plates of 96 wells 5 plates of 96 wells 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Autoimmune Regulator (AIRE) in samples from Tissue homogenates and other biological fluids. with no significant corss-reactivity with analogues from other species.

Human Autoimmune Regulator (AIRE) ELISA Kit
abx570732-96tests	Abbexa	96 tests	EUR 707

Human Autoimmune Regulator (AIRE) ELISA Kit
abx250784-96tests	Abbexa	96 tests	EUR 707

Human Autoimmune Regulator (AIRE) ELISA Kit
20-abx150773	Abbexa	EUR 7378.00 EUR 3933.00 EUR 911.00	10 × 96 tests 5 × 96 tests 96 tests

Human Autoimmune Regulator (AIRE) ELISA Kit
DLR-AIRE-Hu-48T	DL Develop	48T	EUR 517
Description: A sandwich quantitative ELISA assay kit for detection of Human Autoimmune Regulator (AIRE) in samples from tissue homogenates or other biological fluids.

Human Autoimmune Regulator (AIRE) ELISA Kit
DLR-AIRE-Hu-96T	DL Develop	96T	EUR 673
Description: A sandwich quantitative ELISA assay kit for detection of Human Autoimmune Regulator (AIRE) in samples from tissue homogenates or other biological fluids.

Human Autoimmune Regulator (AIRE) ELISA Kit
RD-AIRE-Hu-48Tests	Reddot Biotech	48 Tests	EUR 521

Human Autoimmune Regulator (AIRE) ELISA Kit
RD-AIRE-Hu-96Tests	Reddot Biotech	96 Tests	EUR 723

Human AIRE/ Autoimmune regulator ELISA Kit
E0100Hu	Sunlong	1 Kit	EUR 605

Human Autoimmune Regulator (AIRE) ELISA Kit
RDR-AIRE-Hu-48Tests	Reddot Biotech	48 Tests	EUR 544

Human Autoimmune Regulator (AIRE) ELISA Kit
RDR-AIRE-Hu-96Tests	Reddot Biotech	96 Tests	EUR 756

ELISA kit for Human Autoimmune regulator
EK3200	SAB	96 tests	EUR 553
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Autoimmune regulator in samples from serum, plasma, tissue homogenates and other biological fluids.

Human AIRE(Autoimmune regulator) ELISA Kit
EH1501	FN Test	96T	EUR 524.1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml

Human Autoimmune Regulator(AIRE)ELISA Kit
QY-E00071	Qayee Biotechnology	96T	EUR 361

Autoimmune regulator Antibody
48041-100ul	SAB	100ul	EUR 333

Autoimmune regulator Antibody
48041-50ul	SAB	50ul	EUR 239

ELISA kit for Human Autoimmune regulator (AIRE)
KTE60636-48T	Abbkine	48T	EUR 332
Description: Quantitative sandwich ELISA for measuring Human Autoimmune regulator (AIRE) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Autoimmune regulator (AIRE)
KTE60636-5platesof96wells	Abbkine	5 plates of 96 wells	EUR 2115
Description: Quantitative sandwich ELISA for measuring Human Autoimmune regulator (AIRE) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Autoimmune regulator (AIRE)
KTE60636-96T	Abbkine	96T	EUR 539
Description: Quantitative sandwich ELISA for measuring Human Autoimmune regulator (AIRE) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human AIRE (Autoimmune Regulator)
E-EL-H0536	Elabscience Biotech	1 plate of 96 wells	EUR 534
Description: A sandwich ELISA kit for quantitative measurement of Human AIRE (Autoimmune Regulator) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human AIRE (Autoimmune Regulator)
ELK3194	ELK Biotech	1 plate of 96 wells	EUR 432
Description: A sandwich ELISA kit for detection of Autoimmune Regulator from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Mouse Autoimmune regulator, Aire ELISA KIT
ELI-11972m	Lifescience Market	96 Tests	EUR 865

Mouse Autoimmune Regulator (AIRE) ELISA Kit
SEC322Mu-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	EUR 4862.4
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Autoimmune Regulator (AIRE) in Tissue homogenates and other biological fluids.

Mouse Autoimmune Regulator (AIRE) ELISA Kit
SEC322Mu-1x48wellstestplate	Cloud-Clone	1x48-wells test plate	EUR 488.08
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Autoimmune Regulator (AIRE) in Tissue homogenates and other biological fluids.

Mouse Autoimmune Regulator (AIRE) ELISA Kit
SEC322Mu-1x96wellstestplate	Cloud-Clone	1x96-wells test plate	EUR 654.4
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Autoimmune Regulator (AIRE) in Tissue homogenates and other biological fluids.

Mouse Autoimmune Regulator (AIRE) ELISA Kit
SEC322Mu-5x96wellstestplate	Cloud-Clone	5x96-wells test plate	EUR 2644.8
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Autoimmune Regulator (AIRE) in Tissue homogenates and other biological fluids.

Mouse Autoimmune Regulator (AIRE) ELISA Kit
4-SEC322Mu	Cloud-Clone	EUR 4913.00 EUR 2595.00 EUR 655.00	10 plates of 96 wells 5 plates of 96 wells 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Autoimmune Regulator (AIRE) in samples from Tissue homogenates and other biological fluids. with no significant corss-reactivity with analogues from other species.

Guinea pig Autoimmune Regulator ELISA kit
E05A0527-192T	BlueGene	192 tests	EUR 1270
Description: A sandwich ELISA for quantitative measurement of Guinea pig Autoimmune Regulator in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Autoimmune Regulator ELISA kit
E05A0527-48	BlueGene	1 plate of 48 wells	EUR 520
Description: A sandwich ELISA for quantitative measurement of Guinea pig Autoimmune Regulator in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Autoimmune Regulator ELISA kit
E05A0527-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A sandwich ELISA for quantitative measurement of Guinea pig Autoimmune Regulator in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Autoimmune Regulator (AIRE) ELISA Kit
abx570926-96tests	Abbexa	96 tests	EUR 739

Rabbit Autoimmune Regulator (AIRE) ELISA Kit
abx363707-96tests	Abbexa	96 tests	EUR 825

Pig Autoimmune Regulator (AIRE) ELISA Kit
abx360670-96tests	Abbexa	96 tests	EUR 825

Chicken Autoimmune Regulator (AIRE) ELISA Kit
abx355828-96tests	Abbexa	96 tests	EUR 825

Monkey Autoimmune Regulator (AIRE) ELISA Kit
abx359019-96tests	Abbexa	96 tests	EUR 825

Mouse Autoimmune Regulator (AIRE) ELISA Kit
20-abx153694	Abbexa	EUR 7378.00 EUR 3933.00 EUR 911.00	10 × 96 tests 5 × 96 tests 96 tests

Mouse Autoimmune Regulator (AIRE) ELISA Kit
DLR-AIRE-Mu-48T	DL Develop	48T	EUR 527
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Autoimmune Regulator (AIRE) in samples from tissue homogenates or other biological fluids.

Mouse Autoimmune Regulator (AIRE) ELISA Kit
DLR-AIRE-Mu-96T	DL Develop	96T	EUR 688
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Autoimmune Regulator (AIRE) in samples from tissue homogenates or other biological fluids.

Mouse Autoimmune Regulator (AIRE) ELISA Kit
RD-AIRE-Mu-48Tests	Reddot Biotech	48 Tests	EUR 533

Mouse Autoimmune Regulator (AIRE) ELISA Kit
RD-AIRE-Mu-96Tests	Reddot Biotech	96 Tests	EUR 740

Mouse Autoimmune Regulator (AIRE) ELISA Kit
RDR-AIRE-Mu-48Tests	Reddot Biotech	48 Tests	EUR 557

Mouse Autoimmune Regulator (AIRE) ELISA Kit
RDR-AIRE-Mu-96Tests	Reddot Biotech	96 Tests	EUR 774

Human Autoimmune Regulator (AIRE) CLIA Kit
20-abx493615	Abbexa	EUR 7973.00 EUR 4246.00 EUR 981.00	10 × 96 tests 5 × 96 tests 96 tests

Human Autoimmune Regulator (AIRE) CLIA Kit
abx196471-96tests	Abbexa	96 tests	EUR 825

Human Autoimmune Regulator (AIRE) Protein
20-abx652629	Abbexa	EUR 578.00 EUR 258.00 EUR 1720.00 EUR 690.00 EUR 425.00	100 ug 10 ug 1 mg 200 ug 50 ug

Autoimmune Regulator (AIRE) Antibody
abx117155-100ug	Abbexa	100 ug	EUR 467

Autoimmune Regulator (AIRE) Antibody
20-abx312575	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Autoimmune Regulator (AIRE) Antibody
20-abx323992	Abbexa	EUR 314.00 EUR 244.00	100 ug 50 ug

Autoimmune Regulator (AIRE) Antibody
20-abx175527	Abbexa	EUR 1205.00 EUR 578.00	1 mg 200 ug

Autoimmune Regulator (AIRE) Antibody
20-abx175528	Abbexa	EUR 1233.00 EUR 592.00	1 mg 200 ug

Autoimmune Regulator (AIRE) Antibody
20-abx175529	Abbexa	EUR 1233.00 EUR 592.00	1 mg 200 ug

Autoimmune Regulator (AIRE) Antibody
20-abx171376	Abbexa	EUR 857.00 EUR 439.00	1 mg 200 ug

Autoimmune Regulator (AIRE) Antibody
abx230241-100ug	Abbexa	100 ug	EUR 481

Autoimmune Regulator (AIRE) Antibody
abx331461-100ul	Abbexa	100 ul	EUR 425

Autoimmune Regulator (AIRE) Antibody
20-abx325675	Abbexa	EUR 314.00 EUR 244.00	100 ug 50 ug

Autoimmune Regulator (AIRE) Antibody
20-abx001466	Abbexa	EUR 411.00 EUR 592.00 EUR 182.00 EUR 314.00	100 ul 200 ul 20 ul 50 ul

Autoimmune Regulator (AIRE) Antibody
abx038141-100ug	Abbexa	100 ug	EUR 391

Autoimmune Regulator (AIRE) Antibody
20-abx007582	Abbexa	EUR 300.00 EUR 439.00 EUR 189.00	100 ul 200 ul 30 ul

Autoimmune Regulator (AIRE) Antibody
20-abx013298	Abbexa	EUR 314.00 EUR 98.00 EUR 398.00 EUR 495.00	100 ug 10 ug 200 ug 300 µg

Autoimmune Regulator (AIRE) Antibody
abx019018-100ug	Abbexa	100 ug	EUR 342

Autoimmune regulator (AIRE) Antibody
48129-100ul	SAB	100ul	EUR 333

Autoimmune regulator (AIRE) Antibody
48129-50ul	SAB	50ul	EUR 239

Autoimmune regulator (AIRE) Antibody
48149-100ul	SAB	100ul	EUR 333

Autoimmune regulator (AIRE) Antibody
48149-50ul	SAB	50ul	EUR 239

Aire ELISA Kit| Mouse Autoimmune regulator ELISA Kit
EF014266	Lifescience Market	96 Tests	EUR 689

Guinea pig Autoimmune Regulator (AIRE) ELISA Kit
abx358142-96tests	Abbexa	96 tests	EUR 825

ELISA kit for Mouse AIRE (Autoimmune Regulator)
ELK6262	ELK Biotech	1 plate of 96 wells	EUR 432
Description: A sandwich ELISA kit for detection of Autoimmune Regulator from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

ELISA kit for Mouse Autoimmune regulator (AIRE)
KTE70434-48T	Abbkine	48T	EUR 332
Description: Quantitative sandwich ELISA for measuring Mouse Autoimmune regulator (AIRE) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse Autoimmune regulator (AIRE)
KTE70434-5platesof96wells	Abbkine	5 plates of 96 wells	EUR 2115
Description: Quantitative sandwich ELISA for measuring Mouse Autoimmune regulator (AIRE) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse Autoimmune regulator (AIRE)
KTE70434-96T	Abbkine	96T	EUR 539
Description: Quantitative sandwich ELISA for measuring Mouse Autoimmune regulator (AIRE) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

CLIA kit for Human AIRE (Autoimmune Regulator)
E-CL-H0428	Elabscience Biotech	1 plate of 96 wells	EUR 584
Description: A sandwich CLIA kit for quantitative measurement of Human AIRE (Autoimmune Regulator) in samples from Serum, Plasma, Cell supernatant

Mouse Autoimmune Regulator (AIRE) CLIA Kit
20-abx493616	Abbexa	EUR 7973.00 EUR 4246.00 EUR 981.00	10 × 96 tests 5 × 96 tests 96 tests

Autoimmune Regulator (AIRE) Antibody (HRP)
20-abx312576	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Autoimmune Regulator (AIRE) Antibody (FITC)
20-abx312577	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Autoimmune Regulator (AIRE) Antibody (Biotin)
20-abx312578	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Mouse Autoimmune Regulator (AIRE) Protein
20-abx652630	Abbexa	EUR 578.00 EUR 258.00 EUR 1720.00 EUR 690.00 EUR 425.00	100 ug 10 ug 1 mg 200 ug 50 ug

Mouse Autoimmune Regulator (AIRE) Protein
20-abx652631	Abbexa	EUR 578.00 EUR 258.00 EUR 1720.00 EUR 690.00 EUR 425.00	100 ug 10 ug 1 mg 200 ug 50 ug

Autoimmune regulator (AIRE) Conjugated Antibody
C48129	SAB	100ul	EUR 397

Autoimmune Regulator Phospho-Ser156 (AIRE pS156) Antibody
20-abx323993	Abbexa	EUR 314.00 EUR 244.00	100 ug 50 ug

Autoimmune Regulator Phospho-Ser156 (AIRE pS156) Antibody
20-abx012667	Abbexa	EUR 314.00 EUR 98.00 EUR 398.00 EUR 495.00	100 ug 10 ug 200 ug 300 µg

Custom Antibody titration by ELISA up to 2 rabbits and 1 bleed
ELISA-1	Alpha Diagnostics	1	EUR 202

Eapa2 ELISA Kit| Mouse Experimental autoimmune prostatitis antig
EF013407	Lifescience Market	96 Tests	EUR 689

Frit Kit
FRIT-KIT	Next Advance	1each	EUR 124
Description: Kit to create frits in capillaries. Includes formamide, Kasil-1, Kasil-1624 and a cleaving tool.

Human SLC2A4 regulator, SLC2A4RG ELISA KIT
ELI-18373h	Lifescience Market	96 Tests	EUR 824

Human Apoptosis regulator BAX ELISA kit
E01A1782-192T	BlueGene	192 tests	EUR 1270
Description: A sandwich ELISA for quantitative measurement of Human Apoptosis regulator BAX in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Apoptosis regulator BAX ELISA kit
E01A1782-48	BlueGene	1 plate of 48 wells	EUR 520
Description: A sandwich ELISA for quantitative measurement of Human Apoptosis regulator BAX in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Apoptosis regulator BAX ELISA kit
E01A1782-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A sandwich ELISA for quantitative measurement of Human Apoptosis regulator BAX in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Apoptosis regulator BAX ELISA Kit
CSB-E09344h-24T	Cusabio	1 plate of 24 wells	EUR 165
Description: Quantitativesandwich ELISA kit for measuring Human Apoptosis regulator BAX in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Apoptosis regulator BAX ELISA Kit
1-CSB-E09344h	Cusabio	EUR 703.00 EUR 4843.00 EUR 2570.00	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Apoptosis regulator BAX in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Column Packing Kit
PACK-KIT	Next Advance	1pack	EUR 1035
Description: Column packing kit for pressure cells. Includes: HPREG regulator, TBNG10 tubing, CAP-75 capillary, and STRB5X2 stir bar.

PCR Mycoplasma Detection Kit
M034-Kit	TOKU-E	Kit	EUR 266

Mouse Eapa2/ Experimental autoimmune prostatitis antigen 2 ELISA Kit
E0435Mo	Sunlong	1 Kit	EUR 632

ELISA kit for Mouse Experimental autoimmune prostatitis antigen 2
EK4826	SAB	96 tests	EUR 670
Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse Experimental autoimmune prostatitis antigen 2 in samples from serum, plasma, tissue homogenates and other biological fluids.

Mouse Eapa2(Experimental autoimmune prostatitis antigen 2) ELISA Kit
EM0797	FN Test	96T	EUR 567.6
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 0.094 ng/ml

Cas9 Protein and T7 gRNA SmartNuclease Synthesis Kit
CAS400A-KIT	SBI	1 kit (10 rxn)	EUR 1110

Experimental Autoimmune Encephalomyelitis Complementary Peptide
5-01126	CHI Scientific	4 x 5mg	Ask for price

Experimental Autoimmune Encephalomyelitis Complementary Peptide
20-abx266248	Abbexa	EUR 467.00 EUR 759.00 EUR 342.00	10 mg 25 mg 5 mg

Glucokinase Regulator Cell ELISA Kit
abx595841-96tests	Abbexa	96 tests	EUR 637

Human Transcriptional regulator ERG, ERG ELISA KIT
ELI-10025h	Lifescience Market	96 Tests	EUR 824

Human Transcriptional regulator ATRX, ATRX ELISA KIT
ELI-25220h	Lifescience Market	96 Tests	EUR 824

Human Apoptosis regulator BAX, BAX ELISA KIT
ELI-04433h	Lifescience Market	96 Tests	EUR 824

Human Transcriptional regulator Kaiso, ZBTB33 ELISA KIT
ELI-08145h	Lifescience Market	96 Tests	EUR 824

Human Bifunctional apoptosis regulator(BFAR) ELISA kit
E01B0794-192T	BlueGene	192 tests	EUR 1270
Description: A sandwich ELISA for quantitative measurement of Human Bifunctional apoptosis regulator(BFAR) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Bifunctional apoptosis regulator(BFAR) ELISA kit
E01B0794-48	BlueGene	1 plate of 48 wells	EUR 520
Description: A sandwich ELISA for quantitative measurement of Human Bifunctional apoptosis regulator(BFAR) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Bifunctional apoptosis regulator(BFAR) ELISA kit
E01B0794-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A sandwich ELISA for quantitative measurement of Human Bifunctional apoptosis regulator(BFAR) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Transcriptional regulator ERG(ERG) ELISA kit
E01T0612-192T	BlueGene	192 tests	EUR 1270
Description: A competitive ELISA for quantitative measurement of Human Transcriptional regulator ERG(ERG) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Transcriptional regulator ERG(ERG) ELISA kit
E01T0612-48	BlueGene	1 plate of 48 wells	EUR 520
Description: A competitive ELISA for quantitative measurement of Human Transcriptional regulator ERG(ERG) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Transcriptional regulator ERG(ERG) ELISA kit
E01T0612-96	BlueGene	1 plate of 96 wells	EUR 685
Description: A competitive ELISA for quantitative measurement of Human Transcriptional regulator ERG(ERG) in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Bifunctional Apoptosis Regulator (BFAR) ELISA Kit
SEJ556Hu-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	EUR 4731.5
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Bifunctional Apoptosis Regulator (BFAR) in Tissue homogenates, cell lysates and other biological fluids.

Human Bifunctional Apoptosis Regulator (BFAR) ELISA Kit
SEJ556Hu-1x48wellstestplate	Cloud-Clone	1x48-wells test plate	EUR 477.3
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Bifunctional Apoptosis Regulator (BFAR) in Tissue homogenates, cell lysates and other biological fluids.

Human Bifunctional Apoptosis Regulator (BFAR) ELISA Kit
SEJ556Hu-1x96wellstestplate	Cloud-Clone	1x96-wells test plate	EUR 639
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Bifunctional Apoptosis Regulator (BFAR) in Tissue homogenates, cell lysates and other biological fluids.

Human Bifunctional Apoptosis Regulator (BFAR) ELISA Kit
SEJ556Hu-5x96wellstestplate	Cloud-Clone	5x96-wells test plate	EUR 2575.5
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Bifunctional Apoptosis Regulator (BFAR) in Tissue homogenates, cell lysates and other biological fluids.

Human Bifunctional Apoptosis Regulator (BFAR) ELISA Kit
4-SEJ556Hu	Cloud-Clone	EUR 4782.00 EUR 2526.00 EUR 640.00	10 plates of 96 wells 5 plates of 96 wells 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Bifunctional Apoptosis Regulator (BFAR) in samples from Tissue homogenates, cell lysates and other biological fluids. with no significant corss-reactivity with analogues from other species.

Human Bifunctional apoptosis regulator, BFAR ELISA KIT
ELI-34714h	Lifescience Market	96 Tests	EUR 824

Human Pleiotropic regulator 1, PLRG1 ELISA KIT
ELI-38038h	Lifescience Market	96 Tests	EUR 824

Human Lysosomal- trafficking regulator, LYST ELISA KIT
ELI-48080h	Lifescience Market	96 Tests	EUR 824

Human MIER1 Transcriptional Regulator (MIER1) ELISA Kit
abx381449-96tests	Abbexa	96 tests	EUR 911

Human Pleiotropic Regulator 1 (PLRG1) ELISA Kit
abx382300-96tests	Abbexa	96 tests	EUR 911

Human Bifunctional Apoptosis Regulator (BFAR) ELISA Kit
abx384630-96tests	Abbexa	96 tests	EUR 911

Human Lysosomal Trafficking Regulator (LYST) ELISA Kit
abx385111-96tests	Abbexa	96 tests	EUR 911

Human Transcriptional regulator Kaiso (ZBTB33) ELISA Kit
abx385521-96tests	Abbexa	96 tests	EUR 911

Human Transcriptional Regulator ERG (ERG) ELISA Kit
abx387181-96tests	Abbexa	96 tests	EUR 911

Human Bifunctional Apoptosis Regulator (BFAR) ELISA Kit
20-abx156882	Abbexa	EUR 7378.00 EUR 3933.00 EUR 911.00	10 × 96 tests 5 × 96 tests 96 tests

Human Interferon Production Regulator (IFNR) ELISA Kit
abx050082-96tests	Abbexa	96 tests	EUR 621

Human BAX/ Apoptosis regulator BAX ELISA Kit
E0254Hu	Sunlong	1 Kit	EUR 563

Human ERG(Transcriptional regulator ERG) ELISA Kit
EH4920	FN Test	96T	EUR 567.6
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml

Human BAX(Apoptosis regulator BAX) ELISA Kit
EH0669	FN Test	96T	EUR 524.1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.469 ng/ml

Human Pleiotropic Regulator 1(PLRG1)ELISA Kit
QY-E03727	Qayee Biotechnology	96T	EUR 400

CMV-hspCas9-T2A-Puro SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit
CASLV100PA-KIT	SBI	1 Kit	EUR 1132

CMV-hspCas9-EF1-GFP SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit
CASLV105PA-KIT	SBI	1 Kit	EUR 1132

MSCV-hspCas9-T2A-Puro SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit
CASLV120PA-KIT	SBI	1 Kit	EUR 1132

MSCV-hspCas9-EF1-GFP SmartNuclease Lentivector Plasmid + LentiStarter Packaging Kit
CASLV125PA-KIT	SBI	1 Kit	EUR 1132

Multiplex gRNA Kit + EF1-T7-hspCas9-H1-gRNA linearized SmartNuclease vector
CAS700A-KIT	SBI	10 rxn	EUR 1132

Multiplex gRNA Kit + CAG-T7-hspCas9-H1-gRNA linearized SmartNuclease vector
CAS720A-KIT	SBI	10 rxn	EUR 1132

Multiplex gRNA Kit + CMV-T7-hspCas9-H1-gRNA linearized SmartNuclease vector
CAS740A-KIT	SBI	10 rxn	EUR 1132

Rat Eapa2/ Experimental autoimmune prostatitis antigen 2 homolog ELISA Kit
E0313Ra	Sunlong	1 Kit	EUR 646

T7 gRNA SmartNuclease Synthesis Kit (includes CAS510A-1 & T7 IVT synthesis reagents)
CAS510A-KIT	SBI	1 Kit	EUR 805

Cas9 Nickase: CMV-hspCas9(D10A)-T2A-Puro SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit
CASLV200PA-KIT	SBI	1 Kit	EUR 1132

Cas9 Nickase: CMV-hspCas9(D10A)-EF1-GFP SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit
CASLV205PA-KIT	SBI	1 Kit	EUR 1132

Cas9 Nickase: MSCV-hspCas9(D10A)-T2A-Puro SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit
CASLV220PA-KIT	SBI	1 Kit	EUR 1132

Cas9 Nickase: MSCV-hspCas9(D10A)-EF1-GFP SmartNickase Lentivector Plasmid + LentiStarter Packaging Kit
CASLV225PA-KIT	SBI	1 Kit	EUR 1132

Multiplex gRNA Kit + Cas9 Nickase: EF1-T7-hspCas9-nickase-H1-gRNA linearized SmartNickase vector
CAS750A-KIT	SBI	10 rxn	EUR 1132

Multiplex gRNA Kit + Cas9 Nickase: CAG-T7-hspCas9-nickase-H1-gRNA linearized SmartNickase vector
CAS770A-KIT	SBI	10 rxn	EUR 1132

Multiplex gRNA Kit + Cas9 Nickase: CMV-T7-hspCas9-nickase-H1-gRNA linearized SmartNickase vector
CAS790A-KIT	SBI	10 rxn	EUR 1132

Cas9 SmartNuclease Extra Ligation Kit [includes 5x ligation buffer (10 ul) and Fast ligase (2.5ul)]
CAS9LIG-KIT	SBI	1 Kit	EUR 153

However, in our case, DHTR on account of a major immune response, which is even rarer in DHTR circumstances, developed twice inside a brief interval. A historical past of transfusion and being pregnant in addition to preexisting irregular antibodies have been recognized as danger components for DHTR. Thus, extra consideration must be paid to the danger of DHTR redevelopment by repeated transfusions.